Profiling of substrate specificity of SARS-CoV 3CL.
Identifieur interne : 002475 ( Main/Exploration ); précédent : 002474; suivant : 002476Profiling of substrate specificity of SARS-CoV 3CL.
Auteurs : Chi-Pang Chuck [République populaire de Chine] ; Lin-Tat Chong ; Chao Chen ; Hak-Fun Chow ; David Chi-Cheong Wan ; Kam-Bo WongSource :
- PloS one [ 1932-6203 ] ; 2010.
Descripteurs français
- KwdFr :
- MESH :
- enzymologie : Virus du SRAS.
- métabolisme : Cysteine endopeptidases, Protéines virales.
- Hydrolyse, Spécificité du substrat, Transfert d'énergie par résonance de fluorescence.
English descriptors
- KwdEn :
- MESH :
- chemical , metabolism : Cysteine Endopeptidases, Viral Proteins.
- enzymology : SARS Virus.
- Fluorescence Resonance Energy Transfer, Hydrolysis, Substrate Specificity.
Abstract
The 3C-like protease (3CL(pro)) of severe acute respiratory syndrome-coronavirus is required for autoprocessing of the polyprotein, and is a potential target for treating coronaviral infection.
DOI: 10.1371/journal.pone.0013197
PubMed: 20949131
Affiliations:
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Le document en format XML
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<affiliation wicri:level="4"><nlm:affiliation>School of Biochemical Sciences, The Chinese University of Hong Kong, Sha Tin, Hong Kong, China.</nlm:affiliation>
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<author><name sortKey="Chong, Lin Tat" sort="Chong, Lin Tat" uniqKey="Chong L" first="Lin-Tat" last="Chong">Lin-Tat Chong</name>
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<author><name sortKey="Chen, Chao" sort="Chen, Chao" uniqKey="Chen C" first="Chao" last="Chen">Chao Chen</name>
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<author><name sortKey="Chow, Hak Fun" sort="Chow, Hak Fun" uniqKey="Chow H" first="Hak-Fun" last="Chow">Hak-Fun Chow</name>
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<author><name sortKey="Wan, David Chi Cheong" sort="Wan, David Chi Cheong" uniqKey="Wan D" first="David Chi-Cheong" last="Wan">David Chi-Cheong Wan</name>
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<author><name sortKey="Wong, Kam Bo" sort="Wong, Kam Bo" uniqKey="Wong K" first="Kam-Bo" last="Wong">Kam-Bo Wong</name>
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<affiliation wicri:level="4"><nlm:affiliation>School of Biochemical Sciences, The Chinese University of Hong Kong, Sha Tin, Hong Kong, China.</nlm:affiliation>
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<author><name sortKey="Chong, Lin Tat" sort="Chong, Lin Tat" uniqKey="Chong L" first="Lin-Tat" last="Chong">Lin-Tat Chong</name>
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<author><name sortKey="Chen, Chao" sort="Chen, Chao" uniqKey="Chen C" first="Chao" last="Chen">Chao Chen</name>
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<author><name sortKey="Chow, Hak Fun" sort="Chow, Hak Fun" uniqKey="Chow H" first="Hak-Fun" last="Chow">Hak-Fun Chow</name>
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<author><name sortKey="Wong, Kam Bo" sort="Wong, Kam Bo" uniqKey="Wong K" first="Kam-Bo" last="Wong">Kam-Bo Wong</name>
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<series><title level="j">PloS one</title>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Cysteine Endopeptidases (metabolism)</term>
<term>Fluorescence Resonance Energy Transfer</term>
<term>Hydrolysis</term>
<term>SARS Virus (enzymology)</term>
<term>Substrate Specificity</term>
<term>Viral Proteins (metabolism)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Cysteine endopeptidases (métabolisme)</term>
<term>Hydrolyse</term>
<term>Protéines virales (métabolisme)</term>
<term>Spécificité du substrat</term>
<term>Transfert d'énergie par résonance de fluorescence</term>
<term>Virus du SRAS (enzymologie)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Cysteine Endopeptidases</term>
<term>Viral Proteins</term>
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<keywords scheme="MESH" qualifier="enzymologie" xml:lang="fr"><term>Virus du SRAS</term>
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<keywords scheme="MESH" qualifier="enzymology" xml:lang="en"><term>SARS Virus</term>
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<keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Cysteine endopeptidases</term>
<term>Protéines virales</term>
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<keywords scheme="MESH" xml:lang="en"><term>Fluorescence Resonance Energy Transfer</term>
<term>Hydrolysis</term>
<term>Substrate Specificity</term>
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<keywords scheme="MESH" xml:lang="fr"><term>Hydrolyse</term>
<term>Spécificité du substrat</term>
<term>Transfert d'énergie par résonance de fluorescence</term>
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<front><div type="abstract" xml:lang="en">The 3C-like protease (3CL(pro)) of severe acute respiratory syndrome-coronavirus is required for autoprocessing of the polyprotein, and is a potential target for treating coronaviral infection.</div>
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<tree><noCountry><name sortKey="Chen, Chao" sort="Chen, Chao" uniqKey="Chen C" first="Chao" last="Chen">Chao Chen</name>
<name sortKey="Chong, Lin Tat" sort="Chong, Lin Tat" uniqKey="Chong L" first="Lin-Tat" last="Chong">Lin-Tat Chong</name>
<name sortKey="Chow, Hak Fun" sort="Chow, Hak Fun" uniqKey="Chow H" first="Hak-Fun" last="Chow">Hak-Fun Chow</name>
<name sortKey="Wan, David Chi Cheong" sort="Wan, David Chi Cheong" uniqKey="Wan D" first="David Chi-Cheong" last="Wan">David Chi-Cheong Wan</name>
<name sortKey="Wong, Kam Bo" sort="Wong, Kam Bo" uniqKey="Wong K" first="Kam-Bo" last="Wong">Kam-Bo Wong</name>
</noCountry>
<country name="République populaire de Chine"><noRegion><name sortKey="Chuck, Chi Pang" sort="Chuck, Chi Pang" uniqKey="Chuck C" first="Chi-Pang" last="Chuck">Chi-Pang Chuck</name>
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